Androgens can cause the growth of prostate cancer cells. Drugs, such as enzalutamide, abiraterone acetate, and prednisone, may lessen the amount of androgens made by the body. The purpose of this study is to determine whether men treated for localized prostate cancer adhere to a long-term months-years daily intermittent fasting regimen, and to measure the levels of metabolic and prostate-cancer derived microparticles in the serum of men that practice a daily intermittent fasting regimen after treatment for localized, high-risk prostate cancer.
The purpose of this study is to determine whether, in men with post-prostatectomy PSA recurrences, salvage radiation therapy SRT with enhanced anti-androgen therapy with apalutamide will improve biochemical progression-free survival bPFS compared to SRT alone. Proton beam radiation therapy is one of the treatments for men with prostate cancer who have localized disease.
The benefit of the combination with androgen suppression is not completely understood. This study will compare the use of hypofraction proton therapy 28 treatments alone to proton therapy with androgen suppression therapy. Castration-resistant prostate cancer patients with rising prostatic specific antigen PSA are eligible for this study. Patients with. The purpose of this study is to evaouate how well standard systemic therapy with or without definitive treatment prostate removal surgery or radiation therapy works in treating participants with prostate cancer that has spread to other places in the body.
Tissue and blood will be collected before treatment. If patients receive androgen deprivation, then blood will be collected after neoadjuvant androgen deprivation but before radiation, ablative therapies, or surgery. Subsequent samples will be obtained at 3 months and 6 months following treatment, after which no further patient contact will occur. The purpose of this study is to assess the safety and efficacy of pembrolizumab MK combination therapy in patients with metastatic castrate resistant prostate cancer mCRPC.
Outcome measures will be assessed individually for each cohort. The purpose of this study is to evaluate the effectiveness of niraparib in combination with abiraterone acetate and prednisone AA-P compared to AA-P plus placebo. The purpose of this study is to identify DNA methylation genetic markers in non-cancerous prostate tissue, and compare with the markers previously found to be in prostate cancer tissue.
This will provide data that can be used to identify genetic marker profiles to diagnose and provide prognosis for prostate cancer. The purpose of this study is to determine how patients with metastatic castration-resistant prostate cancer, and evidence of a homologous recombination gene deficiency, respond to treatment with rucaparib verses treatment with physician's choice of abiraterone acetate, enzalutamide, or docetaxel.
The purpose of this research is to see if MR-guided cryoablation can effectively treat prostate tumor recurrences.
The aims of this study are to evaluate the prevalence of vitamin D deficiency among AA prostate cancer patients and to determine the deficits in immunity associated with vitamin D deficiency.
Also, we will evaluate whether the peripheral blood immune cell function is different in AA prostate cancer patients with metastatic disease as compared with those with localized disease. The purpose of this study is to collect prostate surgical samples from metastatic patients to establish xenograft tumor lines for future testing of potential therapies and for understanding mechanisms of therapy resistance.
The purpose of this study is to assess the effectiveness of treatment with docetaxel and prednisone, with or without vaccine therapy for patients who have hormone-resistant prostate cancer that has spread to other parts of the body. Drugs used in chemotherapy, such as docetaxel and prednisone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Vaccines made from an antigen may help the body build an effective immune response to kill tumor cells.
It is not yet known whether docetaxel and prednisone are more effective with This is a pilot study to test a hypothesis that a greater increase in serum chromogranin A CgA after a definitive radiotherapy RT with or without androgen deprivation therapy ADT is associated with a higher risk of prostate cancer recurrence after RT.
CgA is also measured at various pre-defined post-RT time points. The study will analyze the followings: 1. Change in CgA level at various pre-defined post-RT time points from the baseline, 2. The purpose of this study is to evaluate androgen-deprivation therapy and radiation therapy in treating patients with prostate cancer.
Androgen deprivation therapy may stop the adrenal glands from making androgens. Radiation therapy uses high-energy x-rays to kill tumor cells. This research trial studies gene expression in patients with metastatic prostate cancer receiving cytochrome P CYP inhibition therapy. Studying samples of tissue, blood, and urine in the laboratory from patients receiving CYP inhibition therapy may help doctors learn more about changes that occur in deoxyribonucleic acid DNA and identify biomarkers related to cancer.
It may also help doctors understand how well patients respond to treatment. The purpose of this study is to determine how patients with metastatic castration-resistant prostate cancer, and evidence of a homologous recombination gene deficiency, respond to treatment with rucaparib.
The purpose of this study is to see how safe and effective abemaciclib is when given together with abiraterone acetate plus prednisone in participants with metastatic castration resistant prostate cancer.
The purpose of this study is to assess how well multiparametric magnetic resonance imaging MRI works in evaluating cancer stage and helping treatment planning in patients with prostate cancer. Multiparametric MRI may be useful for evaluating the type of cancer in finding aggressive disease.
The purpose of this study is to evaluate the prevalence of 4 or more DNA-repair defects in a population of men with metastatic Prostate Cancer PC , and to use the variants reported to assess biomarker eligibility for niraparib interventional studies.
The purpose of this study is to investigate MR-guided cryoablation of biopsy proven Gleason 7 prostate cancers using the Galil MR-compatible cryoablation system to monitor the technqiue and prospectively collect the data.
The system is already FDA k approved for soft tissue ablation and has been utilized successfully at Mayo previously. This phase II pilot trial studies how well bicalutamide and raloxifene hydrochloride work in treating patients with prostate cancer undergoing surgery. Find out about the latest UK research looking into new ways to diagnose and the possible causes of prostate cancer. Before new treatments can be introduced they need to be tested thoroughly. Find out about the latest UK research into the treatment of early prostate cancer.
Read our information about coronavirus and cancer. About Cancer generously supported by Dangoor Education since Before sharing sensitive information, make sure you're on a federal government site. The site is secure. If you are a Veteran in crisis or concerned about one, connect with our caring, qualified responders for confidential help.
Many of them are Veterans themselves. Get more resources at VeteransCrisisLine. Photo for illustrative purposes only. Prostate cancer has historically been considered incurable once it has spread to parts of the body distant from the prostate gland itself. Now, a VA study is examining an innovative treatment approach for men whose prostate cancer has spread to a limited number of distant areas despite initial treatment with surgery or radiation.
Abhishek Solanki. Prostate cancer is the most commonly diagnosed cancer among Veterans in VA. Phase II A drug reaches Phase II only when the FDA has reviewed the Phase I data and concludes that the drug is safe for patients, and that its clinical activity may be beneficial against a particular disease or condition.
At this point, a larger group of patients are enrolled and condition- or disease-specific rating scales are used to record data. The goals are to continue safety assessment and to determine dosage for pivotal, Phase III efficacy trials. Phase III This is an important turning point for drug development. The medication has already passed the rigorous testing and review process required by the FDA, and now it is ready to be studied in an even larger patient population, with even more advanced rating scales and clinical measures.
For example, if patients show clinical improvement after entering the study, how are their activities of daily living improving e. Phase IV studies are often performed to either identify an additional use for an already approved drug, or to gather additional safety information from a larger group of patients. In some cases, Phase IV studies are implemented to establish effectiveness in a subgroup of patients, for example, patients over age The FDA is the governing agency that develops the policies and guidelines for all clinical research, regardless of manufacturer, study phase or drug type.
There are also independent Institutional Review Boards IRB at institutions that review and approve all study-related documents, such as protocols, Informed Consent forms, physician credentials and eligibility, and patient recruitment materials, such as print advertisements and public service announcements.
Why are clinical trials important? There are several reasons why clinical trials are important. First, the participant may have a positive response to the study medication, and his disease or condition may improve. In addition, participants receive free laboratory and medical testing. More often than not, the study medication is in development because it works differently than other drugs on the market, and therefore, it may present an alternative course of treatment for the patient.
What are clinical trials? A clinical trial is the investigation of a new treatment for a disease. The work might be sponsored by a pharmaceutical or biotechnology company, government, university, or a private foundation. The purpose of these studies is to find out whether a new treatment or medical technology such as imaging or medical devices is safe to use and effective for various diseases or medical conditions.
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